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vIHtaHbogh silibinin(silybin)

Source:wikipedia | Updated: Mar 25, 2016

silibinin(INN), je known jesilybin(batlhchaj vo'silybum,genericpongDIghna'vo' bogh extracted 'oH), chaH Dapon 'e' yI pov constituentsilymarin, standardize extractnIm naHjejpuq mixture ngaSflavonolignansconsisting silibinin.isosilibinin,silicristin,silidianinlatlhpu' je. silibinin 'ej QuQ narghtaHvIS 'oH mixture cha'diastereomers, silybin a silybin bIr mIw wIje'laHbe'chugh vaj b, pa' approximately equimolar ratio je.

pharmacology

law'qu'pu' bIQ solubility 'ejbioavailabilityDev silymarin enhance formulations development.silipide(mech pongsiliphos), Qatlh silymarin jephosphatidylcholine(lecithin), ghot tu'lu'. mej 10 poH puS bioavailable puS silymarin.[3]earlierHaDveb bioavailability lulaj siliphos 'e' 4.6. concluded.[4]je ja' silymarin inclusion je β-Qatlhcyclodextrinbe'nI'puqDaj vI'Iprup soluble puS silymarin 'ej QuQ narghtaHvIS 'oH.[5]pa' je qaSmoHlu'glycosidesilybin, solubility bIQ Dunmo' vabDot toblu'pa' hepatoprotective 'angbogh Da je 'ang 'oH.[6]

silymarin. ghaH je latlhflavonoid, 'aghta' inhibitp-glycoprotein-cellular efflux 'oD.[7]chaq ghot'e' p-glycoprotein activity modulation choH absorption 'ej drugs 'ej QuQ p-glycoprotein substrates 'e' bioavailability. inhibits silymarin ja' 'oHcytochrome p450pagh excluded enzymes 'ej interaction je drugs primarily Huv pong p450s.[8]

toxicity

MACHclinical trial phase jIHqaStaHvIS Human je prostate cancer, 'angbogh Da jen dose HaD chut lulajpu'bogh 13 grams daily tu' silibinin toH chergh neH SID 'Itlh prostate cancer je toxicity chej asymptomatic (hyperbilirubinemia'ej elevationalanine aminotransferase) rav commonly legh adverse wanI'.[9]

silymarin je devoid of embryotoxic potential neH Ha'DIbaH ghantoH.[10][11]

medical lo'

lupoQ je drug (legalon® sil (madaus) (d, CH, a) 'ej silimarit_® (bionorica), silymarin product) pa' Sep eu 'op 'ej lo' neH SuQ chej QIH (e.g. iv treatment in case of Hegh yuvtlhe' poinsining); treatment silibinin je chronic hepatits cirrhosis 'ej adjunctive therapy. je leghsilybum_marianum vIlopQo' jay' medicinal_use

potential lo' medical

bopummeH investigation jotlhmeH role chaq ghaj qaStaHvIS cancer treatment (eg muHIvtaHbogh inhibition lulegh silibininSTAT3signalling).[12]

mI' potential mechanisms 'e' laH DIr Dol chepmoH je ghaj silibinin. chemoprotective 'angbogh Da vo' environmental toxins, anti-inflammatory 'angbogh Da, vo' uv induced photocarcinogenesis, protection vo' sunburn, protection vo' uvb-induced epidermal hyperplasia protection DaH nobvam roD 'ej dna QIH induced dna jIpawnIS uv.[13]

biotechnology

laH lIng silymarin neHcallus'ej cells suspensionssilybum marianum'ej lIwpyrazinecarboxamideslaH lo' je abioticelicitorflavolignan production.[14]

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